ABSTRACT
Hepatocellular carcinoma has a high morbidity and mortality, which has seriously harmed human health. Several targeted therapies have been approved for the first- and second-line treatment of advanced hepatocellular carcinoma. The emergence of immunotherapy has brought the treatment of hepatocellular carcinoma into a new era. Targeted and immunotherapeutic agents have synergistic effects in mechanism, also the combination of these two therapies has been clinically beneficial to patients with advanced hepatocellular carcinoma. At the same time, in addition to the systemic therapy of targeted combined immunological, applying appropriate local therapy can provide a longer survival period or even a chance of cure for that some patients. The authors introduce the diagnosis and treatment of a case of advanced hepatocellular carcinoma who achieved pathological complete remission by first-line immunotherapy combined with anti-angiogenesis targeted therapy.
ABSTRACT
OBJECTIVE To study the distribution and drug resistance of coagulase negative Staphylococcus(CNS)that leads to nosocomial infection.METHODS Nosocomial CNS was identified and then drug resistance test was performed by K-B method.Nitrocefin method and the Congo red method were utilized to detect ?-lactamase and the slime,respectively.RESULTS Of all 162 CNS strains isolated,there were 102 strains of MRCNS and 60 strains of MSCNS including 83 S.epidermidis strains,accounting for 51.2%.Among all the MRCNS and MSCNS strains above,the positive rates of the ?-lactamase were 100.0% and 5.0%,respectively,and the positive rates of the slime were 17.6% and 1.7%,respectively.The resistance rates of MRCNS to 12 types of antibiotics were higher than those of MSCNS(P